Practice Quiz

NCLEX-RN

Category - Pharmacological

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A 19-year-old female is admitted for the management of a closed fracture of the left arm. History reveals the patient self-medicated with Tylenol tablets for two weeks before she was taken to the hospital. The patient’s blood is being tested for toxic levels of acetaminophen. Ideally, the test should be done:
  1. 30 minutes after the last dose
  2. One hour after the last dose
  3. Four hours after the last dose
  4. Six hours after the last dose
Explanation
Answer: C - To test for toxicity or therapeutic levels of acetaminophen in the blood, the test should be done four hours after the last known dose. The therapeutic range is within 5-20mcg/ml; a blood level of >150mcg/ml indicates toxicity. Options A and B are incorrect since there isn’t enough time for drug distribution. Acetaminophen toxicity may not manifest outwardly or may present with flu-like symptoms, abdominal pain, and signs of hepatic failure.
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